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Overview

We develop and apply novel biophysical tools to explore the underlying physics behind biological systems, from single molecules, membrane proteins to living cells.​ Specifically, we focus on how cells sense and transmit mechanical cues to chemical signals during their life cycle. Our interdisciplinary group integrates members coming from chemistry, biology, biomedical engineering, and physics backgrounds.

细胞是生物系统的基本单元,细胞内外的各种蛋白如机械零件一样精密协同工作,使得细胞能够在复杂的生理环境中导航并实现其生物学功能。我们实验室主要从事发展和利用新型光子学和生物物理学工具研究细胞运动过程中背后的物理规律(从单分子到活细胞),并探索这些物理规律在生物学中的重要性。具体来说,我们主要聚焦在细胞在生命周期中是如何感知和传递机械线索,以及他们如何利用这些机械信号来调节其自身功能。我们是一个横跨化学、生物医学工程和物理等多个领域的交叉团队,我们研究的最终目标是为肿瘤细胞转移、肿瘤免疫等医学研究提供新的认识和方法。

Lab updates

March 2021 

Our "Reversible Shearing DNA Tension Probe" work has been accepted by Nature Cell Biology-Congrats!

Sep 2019 

Welcome two new graduate students this year,  Piyu Wu and Zhaohui Xiong !

July, 2019

Welcome, Dr. Wei Cheng joined us as a postdoc !

July, 2018 

Welcome Pengxiang Liu as a first year graduate student in the lab!

18 June, 2018 

Group dinner to celebrate the Dragon Boat Festival!

04-05-2018 

We have a brand new TIRF microscope!  Very exciting!

11-01-2017 

Woh, we have lots of fancy instruments now. More will arrive soon.

09-01-2017

Welcome to Wuhan University! The Liu lab is almost operational after Liang Wang, Wenxu, and Hongyun worked hard setting it up over the summer.